A customer recently asked for help with an issue involving the new Adobe X Reader and Internet Explorer 8. In some web sites with scripting opening a pdf in a new window, the window would remain blank and eventually give an error.
It seemed as though it would only open correctly once per reboot. This was extremely frustrating for the customer.
With a little research and testing, we were able to fix the issue by doing the following:
1. Open Adobe Reader X.
2. Press "Ctrl K"
3. Select General Category from the left pane
4. Uncheck the "Enable Protected Mode at Startup" checkbox
5. Click on "Internet" in the left pane
6. Uncheck everything in the window except "Display PDF in browser"
7. Press "OK"
8. Close Adobe X and try to open the document again.
It may not be necessary to uncheck all of these items but this is what we did and it resolved the issue.
I hope this can help someone else save some time.
I should add, another customer mentioned having this same issue 3 days after finding this solution. He was very happy to know there was a simple fix to the problem.